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Continue LogoutArrhythmias often go undetected until patients present with more serious complications, despite having identifiable risk factors that signal risk earlier.1 About 90% of U.S. adults meet the criteria for cardiovascular-kidney-metabolic (CKM) syndrome, a newly defined condition that reflects the combined impact of heart disease, kidney disease, type 2 diabetes, and obesity.2 In practice, that overlap can make it harder to tell when a symptom actually signals an underlying arrhythmia. The traditional pathway for diagnosing arrhythmias often relies on referral from primary care to cardiology.3 Detection may happen later in the care pathway, even for patients who show clear signals earlier in primary care.
Advisory Board recently spoke with Brent Wright, DrPH, RN, MBA, who serves as the Vice President of Global Value, Access, and Population Health at iRhythm Technologies. He started his career as a PICU nurse and now focuses on how earlier detection can improve outcomes while lowering total cost of care. In this Q&A, he discusses where arrhythmia detection breaks down, why gaps persist across the care pathway, and what health systems can do to identify patients earlier.
I tend to think about population health in two different ways. There are programs that focus primarily on collecting data and returning it to physicians, and there are programs that use the data to drive changes in care that improve outcomes. You still see that divide in health systems today, where some teams emphasize data collection and reporting, while others focus on implementing programs that actually move the needle.
Arrhythmias don’t usually sit at the center of those programs. Most population health efforts are built around conditions like heart failure, diabetes, COPD, or chronic kidney disease. What we spend a lot of time doing is connecting arrhythmias to those conditions and showing that they aren’t separate from them. Arrhythmias are part of the same risk profile, and they directly affect both outcomes and cost within populations that systems are already managing.
That perspective changes how you approach detection. Instead of looking for arrhythmias in isolation, you start looking for them within high-risk groups that are already being targeted. That is where we think there is a lot of opportunity to identify patients earlier.
The biggest gap from a care setting perspective is in primary care. Primary care hasn’t traditionally been involved in ambulatory cardiac monitoring, so what happens is a patient presents with symptoms and is referred to cardiology.3 That referral can take 6 to 18 weeks depending on the market, and patients don’t always follow through.
From a population perspective, CKM syndrome patients are one of the most underdiagnosed groups. These patients have overlapping conditions like obesity, diabetes, and chronic kidney disease, and the symptoms of those conditions often look very similar to arrhythmias. Fatigue or dizziness might be attributed to diabetes or another condition instead of being investigated further.
It becomes even more complicated when you consider that diabetic patients are about 25% less likely to experience symptoms with atrial fibrillation.4 That means you have symptom overlap on one hand and, in some cases, limited symptom presentation on the other. Those two dynamics together make it much easier to miss the diagnosis.
The short answer is that the patient population is sicker. If you look at CKM syndrome, about 90% of U.S. adults have at least one risk factor.5 In that environment, arrhythmias are not just a cardiac issue. They have systemic effects. They can change perfusion, affect how well the heart is functioning, and worsen other conditions like chronic kidney disease or heart failure.6-8 As patient conditions could become more complex, arrhythmias become more consequential. Identifying them earlier may influence outcomes across multiple conditions, not just cardiovascular care.9,10
The opportunity is really understanding your patient population at the primary care level, sending the right patients on to specialty care, and then moving them back into primary care when that makes sense, which lowers the cost across that total continuum.
The largest cost drivers show up in the emergency department and inpatient setting, because that is where many of these patients ultimately get diagnosed with an arrhythmia.11 When you compare early detection to late diagnosis, the cost difference is significant. A monitor might range from $300 to $400, while an inpatient hospitalization can range from $20,000 to $25,000.12,13 However, health systems are not always reimbursed for that full duration.14
What this creates is a situation where delayed diagnosis is not just more expensive but also more disruptive operationally. It can tie up inpatient capacity and contributes to the broader access challenges systems are already dealing with.
I don’t think leaders always see the full cost of inaction. It is easy to look at a hospitalization and see the reimbursement associated with it, but that doesn’t capture what happens after discharge or the downstream events that could have been prevented. If you take a step back, earlier detection almost always results in lower cost and better outcomes, which are key drivers of performance under risk-based payment models.10,15,16 With arrhythmias, identifying a patient earlier allows you to intervene sooner and reduce the likelihood of more serious events like stroke, myocardial infarction, or heart failure progression. That makes this not just a clinical decision, but a strategic one for the organization.
A lot of it comes down to access. Primary care and specialty care are both overburdened.17 When the average primary care visit is about 18 minutes, there is limited opportunity to go beyond the primary issue the patient came in for.18 In that setting, providers focus on the most immediate concern, which is understandable. The challenge is that it leaves less room to identify secondary risks like arrhythmias, especially when those symptoms overlap with other conditions. Addressing this likely requires creating a system that supports earlier identification in a way that fits within the realities of clinical practice.
When you move ambulatory cardiac monitoring earlier, you have fewer inappropriate referrals coming from primary care, and you have patients coming into cardiology with a known arrhythmia diagnosis. That allows cardiologists to work more at the top of their license and not spend their time doing differential diagnosis for anxiety or something else that may have driven that patient into cardiology in the first place.
I also think it allows primary care to work more at the top of its license. Primary care can start ruling things in or out without requiring specialty oversight for every single patient. If you look at our national data, about 36% of patients have what we consider a clinically actionable arrhythmia.19 If every patient with symptoms was sent to cardiology without that earlier step, that gives you an answer that about 64% of patients probably did not need to go to cardiology at all. The opportunity is really understanding your patient population at the primary care level, sending the right patients on to specialty care, and then moving them back into primary care when that makes sense, which lowers the cost across that total continuum.
I don’t think most health system leaders really have a strategy for arrhythmia detection today. If you look at conditions like diabetes or heart failure, there are programs built specifically around those populations. There are clear goals around lowering A1C, preventing exacerbations, or managing fluid overload. Arrhythmias, on the other hand, are often treated more like a byproduct without a true strategy around how to identify those patients earlier or which populations to go after.
To me, one of the clearest signs of that gap is in the guidelines. If you look across the major guidelines, they provide extensive guidance on treating atrial fibrillation, but far less guidance on when screening should occur.20,21 That tells you where the system sits today. We know what to do with patients once they are diagnosed, but much less attention has gone toward when we should be looking for arrhythmias in the first place. I think that is the longer process we are trying to support, which is helping organizations see that arrhythmias affect more than just arrhythmias themselves. They affect the patient’s other comorbid conditions, their long-term outcomes, and the total cost of care.22,23
A missed or delayed diagnosis is incredibly expensive, both financially and to the patient. Monitoring patients to rule an arrhythmia in or out is relatively inexpensive.
I think one of the biggest things they should be thinking about is clinical decision support, especially as AI keeps moving so quickly. The ability to search an entire EHR dataset in minutes and identify patients who are at risk is a big shift. I am a nurse, and I have done chart reviews before. They are painful. They take a long time, and they are not an efficient way to identify high-risk patients. I think AI has the potential to make clinical decision support much more meaningful by helping surface patients who should be prioritized for cardiac monitoring or who are not on the right therapy.
At the same time, I don’t think AI should ever take the autonomy away from the physician. I don’t want to go to a hospital and find out everything was decided by AI. It should be an assistive tool that improves clinical vigilance, not something that takes over. Beyond that, I think the most practical priority is supporting primary care and enabling primary care to do more. That could mean billing structures that support ambulatory cardiac monitoring, EHR pathways that make it easier to move patients through the system, or tools that help identify who should be monitored. The challenge is that primary care is already overloaded, so the answer is not just asking them to do more. It is giving them the support to do more without increasing burden.
A missed or delayed diagnosis is incredibly expensive, both financially and to the patient. Monitoring patients to rule an arrhythmia in or out is relatively inexpensive. This is not a rare, high-cost test. We are talking about something that is pretty low-cost compared with what happens downstream if a patient is not diagnosed.
You can have a lot of non-diagnostic monitors and still be very cost effective if you prevent even one hospitalization. That is especially true in value-based care. Even at a 30% to 50% diagnostic yield, the economics can still work if you are reducing emergency department visits, hospitalizations, or major adverse cardiovascular events like stroke, myocardial infarction, or progression to heart failure.
I also think it’s important that people understand this is not just a financial issue. An undiagnosed arrhythmia can create real disruption in a patient’s life, and depending on the arrhythmia, it can lead to very severe outcomes. That is why I would call this low-hanging fruit for health systems and especially for value-based care organizations. It is a relatively inexpensive way to improve patient outcomes while also lowering long-term cost of care.
1 Jaakkol J, Mustonen P, et al. Stroke as the First Manifestation of Atrial Fibrillation. PLoS One. December 9, 2016.
2 American Heart Association Newsroom. “About 9 in 10 haven’t heard of condition that affects nearly 90% of U.S. adults.” October 20, 2025.
3 Working With Your AFib Care Team. American Heart Association. May 14, 2025.
4 Bano A, Rodondi N, et al. Association of Diabetes With Atrial Fibrillation Phenotype and Cardiac and Neurological Comorbidities: Insights From the Swiss‐AF Study. Journal of the American Heart Association. November 10, 2021.
5 Ndumele CE, Rodriguez F, et al. 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. June 6, 2026.
6 Saglietto A, Fois M, et al. A computational analysis of atrial fibrillation effects on coronary perfusion across the different myocardial layers. Scientific Reports. January 17, 2022.
7 Gopinathannair R, Chen LY, et al. Managing Atrial Fibrillation in Patients With Heart Failure and Reduced Ejection Fraction: A Scientific Statement From the American Heart Association. Circulation. June 22, 2021.
8 Bansal N, Charytan DM, et al. Atrial Fibrillation and Stroke Prevention and Management in Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology. June 23, 2026.
9 Turakhia M, Blankestijn PJ, et al. Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. European Heart Journal. June 21, 2018.
10 Kirchhof P, Camm AJ, et al. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. The New England Journal of Medicine. October 1, 2020.
11 Rozen G, Hosseini SM, et al. Emergency Department Visits for Atrial Fibrillation in the United States: Trends in Admission Rates and Economic Burden From 2007 to 2014. Journal of the American Heart Association. July 20, 2018.
12 Heart Rhythm Monitor (Holter, Zio Patch, Event Monitor) Cost. OurHealth Network. July 12, 2026.
13 McDermott D, Hudman J, et al. How costly are common health services in the United States? Peterson-KFF Health System Tracker. November 4, 2020.
14 The Cost of Caring: Challenges Facing America’s Hospitals in 2025. American Hospital Association. April 2025.
15 Davis A, Batra N, et al. Safeguarding Medicare: Proactive care could unlock $500B in annual program savings. Deloitte Center for Health Solutions. September 14, 2025.
16 Wang P, Vienneau M, et al. Reframing value-based care management: Beyond cost reduction and toward patient centeredness. JAMA Health Forum. June 16, 2023.
17 2025 Survey of Physician Appointment Wait Times and Medicare and Medicaid Acceptance Rates. AMN Healthcare. June 2, 2025.
18 Neprash HT, Everhart A, et al. Measuring Primary Care Exam Length Using Electronic Health Record Data. Medical Care. January 30, 2021.
19 Battisti AJ, Pinkerton R, et al. Relationship of Symptom Frequency and Symptom-Rhythm Correlation to Arrhythmia Type and Time to Detection: Insights From Ambulatory Electrocardiogram Monitoring in Over 1 Million Patients. Heart Rhythm. February 2026.
20 Joglar JA, Chung MK, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation. Circulation. January 2, 2024.
21 Tjong FVY, Van Gelder IC. Atrial fibrillation screening: time for precision, not just detection. Cardiovascular Research. February 24, 2026.
22 Ko D, Chung MK, et al. Atrial Fibrillation: A Review. JAMA. December 16, 2024.
23 Peigh G, Zhou J, et al. Impact of Atrial Fibrillation Burden on Health Care Costs and Utilization. JACC: Clinical Electrophysiology. February 28, 2024.
iRhythm is a leading digital health care company that creates solutions that detect, predict, and prevent disease. Combining wearable biosensors and cloud-based data analytics with powerful proprietary algorithms, iRhythm distills data from millions of heartbeats into clinically actionable information. Through a relentless focus on patient care, iRhythm’s vision is to deliver better data, better insights, and better health for all. Learn more about iRhythm’s Population Health Solutions for Arrhythmia Detection.
*Zio® monitor safety information and Zio AT® safety information iRhythm, Zio, Zio XT, Zio AT, MyZio, and ZioSuite are trademarks of iRhythm Technologies, Inc. © 2026 iRhythm Technologies, Inc. MAT-0199-1.
This article is sponsored by iRhythm Technologies, an Advisory Board member organization. Representatives of iRhythm Technologies helped select the topics and issues addressed. Advisory Board experts maintained final editorial approval, and conducted the underlying research independently and objectively. Advisory Board does not endorse any company, organization, product or brand mentioned herein.
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This article is sponsored by iRhythm Technologies. Advisory Board experts conducted the underlying research independently and objectively and maintained final editorial approval.
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