The pandemic may yet again be at a turning point. But this time, it's not due to rising or falling case rates, newly authorized vaccines, or new variants—it's because we may have a new way to treat Covid-19 and view the disease overall.
The most promising Covid-19 drugs in development—beyond vaccines
On Friday, Merck & Co. and Ridgeback Biotherapeutics released new data from a clinical trial showing that their oral antiviral drug molnupiravir reduced the rate of hospitalization or death by roughly 50% in participants with mild or moderate Covid-19. The drug was most effective when given early in the course and was effective regardless of whether patients had the delta or other coronavirus variants.
The results were so promising that the trial's independent monitoring committee recommended stopping the clinical trial early. Merck and Ridgeback plan to ask the FDA for emergency authorization "as soon as possible."
It's not every day that a trial is stopped early for such favorable results—yet while most news coverage of the data was favorable, it largely treated molnupiravir as just one more tool in our toolbox for treating Covid-19.
But to me, this is much bigger than just "one more tool." It represents a potential paradigm shift from focusing on Covid-19 prevention to focusing on mitigation. Such a shift could have several positive and negative ripple effects on the pandemic response.
While molnupiravir is the first oral antiviral to show such promising results against Covid-19, more treatments could be on the horizon, including promising drugs from Pfizer and Roche. If those prove successful, the above factors could become even more important. Further, Merck is studying molnupiravir's potential as a preventative medicine, so it may one day help high-risk individuals avoid getting infected in the first place.
We'll continue to watch the data, open questions, and opportunities and challenges. In the meantime, if you're a health care leader, it's time to start thinking proactively about these treatments and their potential impact on your pandemic response.
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