THE OUTLOOK FOR HEALTH CARE IN 2023:

What you need to know about the forces reshaping our industry.

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Understanding the importance of oncology biomarker testing

    What is oncology biomarker testing?

    Oncology biomarker testing (also known as mutation, genomic, or molecular testing) uses laboratory tests, including companion diagnostics, to help the health care teams gather as much information as possible about a patient’s cancer, ideally before treatment begins, and uncover whether the patient has an actionable biomarker. A companion diagnostic (CDx) is typically an in vitro diagnostic that detects a perfective biomarker to determine whether the patient will respond to a specific treatment.

    As of 2020, there are: 44 FDA-approved companion diagnostic tests on the market and 253 FDA-approved oncology drugs with biomarker indications. Also, most health systems say they do a good job of biomarker testing, specifically in non-small cell lung cancer (NSCLC), but there is a lot of room for improvement:  55% of patients with advanced NSCLC and targetable mutations in one study did not receive targeted therapy and 21% of North American-based oncologists treating metastatic NSCLC made treatment decisions before the patient’s genetic mutation results were available

    Benefits of Oncology biomarker testing

    Health systems

    Advisory Board’s research has found that oncology biomarker testing aligns with many of a health system’s broader strategic goals. In the future, health systems will increasingly use oncology biomarker testing to deliver personalized care to patients and advance their precision medicine initiatives.

    Biomarker testing can also help organizations drive towards value-based care by improving the overall value of care across the entire patient journey—from diagnosis to treatment selection and outcomes.

    Additionally, organizations can use biomarker testing to elevate their oncology department. Advisory Board found that best-in-class organizations utilize biomarker testing to help improve outcomes and strengthen the quality of the oncology care they provide.

    Providers

    Providers can use oncology biomarker testing to help make more informed care and treatment decisions based on a patient’s genetic makeup.

    Notably, biomarker testing can help providers get patients on the right treatment, at the right time. In fact, 37.6% of cancer patients in one study of 5954 patients with refractory malignancies had therapeutically actionable genetic alterations, meaning they could be matched to existing drugs, across many different cancer types. Providers can also use biomarker testing to indicate a patient’s increased risk or susceptibility to a given disease, predict the natural history of disease without further intervention, or predict an outcome following an intervention.

    Patients

    Oncology biomarker testing may help improve patients’ treatment success and outcomes. It also allows patients to avoid trial-and-error and more quickly receive the appropriate treatments for their genetic makeup.

    Your role in advancing biomarker testing

    Recommendations from Advisory Board’s research

    1. Assess how biomarker testing supports your strategic priorities.

    Consider how biomarker testing can support your broader organizational goals—whether delivering high-value and appropriate care, advancing precision medicine, or others.

    2. Connect with your VP/service line leader to gauge current performance.

    Evaluate your organization’s current biomarker testing program and processes. Discuss what works well and identify any challenges or barriers when it comes to biomarker testing. Use these discussions to recognize opportunities to standardize biomarker testing across your broader organization.

    3. Invest in necessary infrastructure (e.g., staff, EHR enhancements) to improve process and long-term results.

    Leverage any internal resources (e.g., staff, EHR enhancements) to improve your biomarker testing process. Prioritize among long-lasting, sustainable investments to improve your biomarker testing process.



    About the sponsor

    AstraZeneca focuses on the discovery, development and commercialisation of prescription medicines in Oncology and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology.

    Learn more about AstraZeneca

    This brochure is sponsored by AstraZeneca for educational purposes only. The content, views, and opinions contained within the cheat sheet are copyrighted by Advisory Board and all rights are reserved. Advisory Board experts wrote the content, conducting the underlying research independently and objectively. Advisory Board does not endorse any company, organization, product or brand mentioned herein.

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    Sponsored by
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    This brochure is sponsored by AstraZeneca. Advisory Board experts wrote the report, conducting the underlying research independently and objectively. AstraZeneca had the opportunity to review the brochure.

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