A rare form of breast cancer that often goes undetected on mammograms is rising about 3% each year — now making up more than one in 10 U.S. cases nationwide, Jamie Parkerson reports for ABC News.
According to a new report from the American Cancer Society (ACS), invasive lobular carcinoma, the second most common breast cancer type, is increasing about 3% each year — more than triple the rate of other breast cancers. The report, published in October, found that while about 80% of breast cancers are the invasive ductal type, the lobular cases — once rare — have doubled since the 1970s.
Rebecca Siegel, a scientific director of surveillance research at ACS and coauthor on the report, said that lobular breast cancer has long been overshadowed by other breast cancers because of its early survival rates.
"[I]f you look at five-year survival, actually women with lobular breast cancer do better than ductal breast cancer," Siegel said. "I think that's probably why it hasn't gotten a lot of attention."
However, she added that the long-term outlook is poorer. "For metastatic disease, women with lobular breast cancer are about half as likely to be alive at 10 years," Siegel said.
The report noted that lobular cancers are rising even faster for women under 50, at more than twice the rate of other breast cancers. The disease is most common in white women, with about 14 cases per 100,000 — which is 33% to 55% higher than in other racial and ethnic groups — but the fastest rise, at nearly 4.5% a year, has been seen among Asian American and Pacific Islander women.
Unlike ductal cancers that typically form a lump, "lobular cancers tend to grow in a straight line or sheet-like patterns," said Anita Mamtani, a surgical oncologist specializing in breast cancer at Memorial Sloan Kettering Cancer Center.
This pattern makes the tumors harder to detect on mammograms, she explained. Patients often notice subtle changes instead, such as breast fullness, firmness, swelling, skin redness, nipple changes, or discharge.
Compared with other types of breast cancer, lobular cancers are also less responsive to some treatments and more likely to occur in both breasts, which may contribute to poorer long-term outcomes, according to the ACS report.
Still, early detection significantly improves survival. The five-year survival rate for early-stage lobular breast cancer is about 99%, and overall survival across all stages is roughly 91%.
"We will use a variety of diagnostic tools for most patients but, for lobular cancer, that arsenal will include not only mammograms but also ultrasound, contrast-enhanced mammograms, and MRIs," Mamtani said. With proper screening, lobular cancer can often be caught in its early stages.
Overall, breast cancer deaths have dropped 44% since 1989, but the disease still affects one in eight women and remains a leading cause of cancer death, the ACS report noted. For all breast cancer types, regular mammograms remain the best way to catch disease early.
For women at average risk, the U.S. Preventive Services Task Force recommends screening every two years from ages 40 to 74, while those at higher risk should discuss earlier or more frequent screening with their doctor.
Nearly half of uninsured women skip breast cancer screenings because of cost concerns, the report added, though free or low-cost programs are available through CDC, the National Breast Cancer Foundation, the American Breast Cancer Foundation, and local providers.
Experts also emphasize maintaining a healthy weight, staying active, limiting alcohol, and talking with a healthcare provider about personal risk factors.
(Parkerson, ABC News, 10/7)
Create your free account to access 1 resource, including the latest research and webinars.
You have 1 free members-only resource remaining this month.
1 free members-only resources remaining
1 free members-only resources remaining
You've reached your limit of free insights
Never miss out on the latest innovative health care content tailored to you.
You've reached your limit of free insights
Never miss out on the latest innovative health care content tailored to you.
This content is available through your Curated Research partnership with Advisory Board. Click on ‘view this resource’ to read the full piece
Email ask@advisory.com to learn more
Never miss out on the latest innovative health care content tailored to you.
This is for members only. Learn more.
Never miss out on the latest innovative health care content tailored to you.