As system leaders double down on artificial intelligence (AI) to streamline operations, personalize care, and drive financial sustainability, life sciences organizations face a new reality: the rules of engagement are changing. From executive-level alliances to pilot partnerships, AI is reshaping what health systems value in a collaborator — data transparency, real-world impact, and digital integration. To remain relevant, life sciences leaders must fundamentally rethink how they engage health systems, what they bring to the table, and how they demonstrate value in an increasingly AI-driven landscape.