As reported in the Daily Briefing, even short-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) for myocardial infarction (MI) survivors can increase the risk of a subsequent MI, according to a study in Circulation.
Researchers analyzed data from 83,675 first-time MI patients, of which about 42% took NSAIDs. Ibuprofen was taken most often, but patients also frequently used diclofenac, celecoxib and naproxen.
Over the next five years, 35,257 of those patients experienced another MI. Individuals who took NSAIDs for one week were 45% more likely to have another MI or die, and taking them for more than three months increased the risk for a second MI by 55%. No increased risk was associated with taking naproxen (Searing, Washington Post, 5/16).